ESMFold2: The Bitter Lesson Is Coming for Proteins★ 74
Latent Space·6d ago·Commentary
Latent Space interviews Biohub’s Alex Rives about ESMFold2 and the broader ESM protein modeling stack. The discussion centers on datasets versus inductive bias, and whether protein biology is entering its own Bitter Lesson era. The key implication is that large-scale evolutionary sequence data and open models may become foundations for structure prediction, interaction modeling, and programmable biology.
