ESMFold2: The Bitter Lesson Is Coming for Proteins

Original: 🔬ESMFold2: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub

Biohub’s ESMFold2 pushes open protein structure prediction and design toward scalable biological world models.

Latent Space interviews Biohub’s Alex Rives about ESMFold2 and the broader ESM protein modeling stack. The discussion centers on datasets versus inductive bias, and whether protein biology is entering its own Bitter Lesson era. The key implication is that large-scale evolutionary sequence data and open models may become foundations for structure prediction, interaction modeling, and programmable biology.

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