How Embryos Shape Their Limbs: A Key Discovery of Genetic Brakes

Original: Embryos shape their limbs: a key discovery of "genetic brakes"

Mouse research finds PRC1 and PRC2 help switch off early limb-development genes at the right time.

A Université de Montréal and IRCM team reports in PNAS that Polycomb complexes PRC1 and PRC2 act as genetic brakes during mouse limb development. These systems silence early developmental genes so later programs can proceed. Disrupting one system alters gene expression; disrupting both keeps early genes active and severely compromises normal limb formation.

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